Asxl1 | ASXL transcriptional regulator 1

GeneMGI:2684063

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

7Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



impaired pupillary reflex	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.89x10^-6
decreased sacral vertebrae number	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.77x10^-8
decreased hemoglobin content	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.67x10^-10
decreased mean corpuscular hemoglobin	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.18x10^-13
decreased hematocrit	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.82x10^-5
abnormal cornea morphology	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.59x10^-6
increased lumbar vertebrae number	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.54x10^-8
hyperactivity	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.03x10^-5
increased bone mineral content	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.05x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Asxl1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Asxl1.

Associated images

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Histopathology

There is no histopathology data found for Asxl1.

IMPC related publications

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External links

No external links available for Asxl1.

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*Asxl1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Asxl1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Asxl1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Asxl1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Asxl1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	mouse

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