Ric8b | RIC8 guanine nucleotide exchange factor B

GeneMGI:2682307Synonyms: Ric-8b, Ric-8

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Vision/eye Hematopoietic system Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



cornea opacity	1 supporting dataset	Ric8b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.87x10^-5
increased leukocyte cell number	1 supporting dataset	Ric8b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.47x10^-7
increased basophil cell number	1 supporting dataset	Ric8b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.58x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Ric8b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased lymphocyte cell number	1 supporting dataset	Ric8b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.1x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ric8b.

Associated images

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Histopathology

There is no histopathology data found for Ric8b.

IMPC related publications

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External links

No external links available for Ric8b.

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*Ric8b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ric8b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ric8b^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ric8b^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Ric8b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Ric8b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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