Tent4a | terminal nucleotidyltransferase 4A

GeneMGI:2682295Synonyms: Papd7, LAK-1, +3 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

35Embryo tissues

Phenotypes

Phy. System:



abnormal gallbladder morphology	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
vertebral transformation	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.3x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.57x10^-5
abnormal vertebral arch morphology	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.95x10^-5
abnormal testis morphology	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
enlarged gallbladder	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased anxiety-related response	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.67x10^-7
abnormal vertebrae morphology	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.77x10^-6
hyperactivity	1 supporting dataset	Tent4a^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.47x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tent4a.

Associated images

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Histopathology

There is no histopathology data found for Tent4a.

IMPC related publications

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External links

No external links available for Tent4a.

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*Tent4a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tent4a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Tent4a^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tent4a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Tent4a^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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