Cep135 | centrosomal protein 135

GeneMGI:2681869Synonyms: LOC381644, Cep4

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Vision/eye Skeleton Craniofacial Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal craniofacial morphology	1 supporting dataset	Cep135^em1(IMPC)J	homozygote	E15.5	N/A ^*
polydactyly	1 supporting dataset	Cep135^em1(IMPC)J	homozygote	E15.5	N/A ^*
abnormal lens morphology	1 supporting dataset	Cep135^em1(IMPC)J	heterozygote	Late adult	8.18x10^-7
edema	1 supporting dataset	Cep135^em1(IMPC)J	homozygote	E15.5	N/A ^*
abnormal head morphology	1 supporting dataset	Cep135^em1(IMPC)J	heterozygote	Late adult	2.65x10^-5
decreased circulating serum albumin level	1 supporting dataset	Cep135^em1(IMPC)J	heterozygote	Late adult	1.76x10^-49
abnormal head shape	1 supporting dataset	Cep135^em1(IMPC)J	homozygote	E15.5	N/A ^*
anophthalmia	1 supporting dataset	Cep135^em1(IMPC)J	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Cep135^em1(IMPC)J	homozygote	Early adult	N/A ^*
decreased bone mineral density	1 supporting dataset	Cep135^em1(IMPC)J	heterozygote	Early adult	2.44x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cep135.

Associated images

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Histopathology

There is no histopathology data found for Cep135.

IMPC related publications

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External links

No external links available for Cep135.

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*Cep135^em1(IMPC)J*	Exon Deletion	‌	mouse
*Cep135^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Cep135^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cep135^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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