Zfat | zinc finger and AT hook domain containing

GeneMGI:2681865Synonyms: LOC380993, Zfp406, +1 more

Physiological systems

23 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Embryo Growth/size/body region Hematopoietic system Skeleton Craniofacial Cardiovascular system Mortality/aging

14 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged thymus	2 supporting datasets	Zfat^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Zfat^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Zfat^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal tooth morphology	2 supporting datasets	Zfat^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Zfat^{em1(IMPC)Ccpcz}	homozygote	E15.5	N/A ^*
abnormal thymus morphology	2 supporting datasets	Zfat^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Zfat^{em1(IMPC)Ccpcz}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Zfat^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Zfat^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Zfat^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Zfat.

Associated images

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Histopathology

There is no histopathology data found for Zfat.

IMPC related publications

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External links

No external links available for Zfat.

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*Zfat^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Zfat^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Zfat^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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