Polr3a | polymerase (RNA) III (DNA directed) polypeptide A
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Growth/size/body region Hematopoietic system Skeleton Mortality/aging Renal/urinary system
14 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Polr3aem2(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Polr3aem2(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| enlarged urinary bladder | 1 supporting dataset | Polr3aem2(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| increased mean platelet volume | 1 supporting dataset | Polr3aem2(IMPC)Tcp | heterozygote | Early adult | 6.11x10-7 | ||
| increased bone mineral content | 2 supporting datasets | Polr3aem2(IMPC)Tcp | heterozygote | Early adult | 1.83x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Polr3aem2(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Polr3aem2(IMPC)Tcp | homozygote | E12.5 | N/A * |
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External links
No external links available for Polr3a.
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| Polr3aem1(IMPC)Tcp | Point Mutation | | mouse |
| Polr3aem2(IMPC)Tcp | Point Mutation | | mouse |
| Polr3atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Polr3atm119248(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |