Vsig4 | V-set and immunoglobulin domain containing 4

GeneMGI:2679720Synonyms: CRIg, Z39IG

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

0Associated diseases

Expression examined in:100Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



hyperactivity	6 supporting datasets	Vsig4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.35x10^-12
increased circulating sodium level	1 supporting dataset	Vsig4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.3x10^-5
decreased circulating glucose level	1 supporting dataset	Vsig4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.09x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Vsig4^{tm1b(EUCOMM)Hmgu}	hemizygote	Early adult	0
increased lean body mass	1 supporting dataset	Vsig4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.47x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Vsig4^{tm1b(EUCOMM)Hmgu}	hemizygote	Early adult	3.95x10^-6
increased urine microalbumin level	2 supporting datasets	Vsig4^{tm1b(EUCOMM)Hmgu}	hemizygote	Early adult	4.41x10^-18
decreased mean corpuscular hemoglobin	1 supporting dataset	Vsig4^{tm1b(EUCOMM)Hmgu}	hemizygote	Early adult	4.5x10^-5
increased vertical activity	1 supporting dataset	Vsig4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.79x10^-5
increased lean body mass	2 supporting datasets	Vsig4^{tm1b(EUCOMM)Hmgu}	hemizygote	Early adult	2.49x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vsig4.

Associated images

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Histopathology

There is no histopathology data found for Vsig4.

IMPC related publications

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External links

No external links available for Vsig4.

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*Vsig4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Vsig4^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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