Crb2 | crumbs family member 2

GeneMGI:2679260

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Integument Vision/eye Mortality/aging

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Crb2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal vibrissa morphology	1 supporting dataset	Crb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	5.87x10^-6
abnormal retina morphology	1 supporting dataset	Crb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.06x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Crb2.

Associated images

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Histopathology

There is no histopathology data found for Crb2.

IMPC related publications

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External links

No external links available for Crb2.

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*Crb2^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Crb2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Crb2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Crb2^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Crb2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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