Sh3tc1 | SH3 domain and tetratricopeptide repeats 1

GeneMGI:2678949

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Muscle Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased neutrophil cell number	2 supporting datasets	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.58x10^-8
decreased grip strength	4 supporting datasets	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.62x10^-6
increased circulating bilirubin level	1 supporting dataset	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.14x10^-7
increased monocyte cell number	2 supporting datasets	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.34x10^-8
abnormal vitreous body morphology	1 supporting dataset	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.34x10^-5
decreased circulating triglyceride level	1 supporting dataset	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.88x10^-6
prolonged QT interval	1 supporting dataset	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.76x10^-5
prolonged ST segment	1 supporting dataset	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.85x10^-5
decreased cardiac muscle contractility	1 supporting dataset	Sh3tc1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.09x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sh3tc1.

Associated images

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Histopathology

There is no histopathology data found for Sh3tc1.

IMPC related publications

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External links

No external links available for Sh3tc1.

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*Sh3tc1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sh3tc1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sh3tc1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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