Thoc6 | THO complex 6

GeneMGI:2677480Synonyms: Wdr58, F830014G06Rik

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Embryo Growth/size/body region Respiratory system Behavior/neurological Mortality/aging Cardiovascular system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Thoc6^em5(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased exploration in new environment	2 supporting datasets	Thoc6^em5(IMPC)Tcp	heterozygote	Early adult	9.67x10^-16
abnormal lung morphology	1 supporting dataset	Thoc6^em5(IMPC)Tcp	heterozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Thoc6^em5(IMPC)Tcp	homozygote	E9.5	N/A ^*
decreased vertical activity	1 supporting dataset	Thoc6^em5(IMPC)Tcp	heterozygote	Early adult	2.7x10^-6
embryonic lethality prior to tooth bud stage	1 supporting dataset	Thoc6^em5(IMPC)Tcp	homozygote	E12.5	N/A ^*
decreased locomotor activity	4 supporting datasets	Thoc6^em5(IMPC)Tcp	heterozygote	Early adult	1.02x10^-6
shortened QRS complex duration	1 supporting dataset	Thoc6^em5(IMPC)Tcp	heterozygote	Early adult	2.19x10^-5
enlarged lymph nodes	1 supporting dataset	Thoc6^em5(IMPC)Tcp	heterozygote	Early adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Thoc6^em5(IMPC)Tcp	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Thoc6.

Associated images

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Histopathology

There is no histopathology data found for Thoc6.

IMPC related publications

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External links

No external links available for Thoc6.

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*Thoc6^em5(IMPC)Tcp*	Indel	‌	mouse
*Thoc6^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Thoc6^{tm451707(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes