Pdzd8 | PDZ domain containing 8

GeneMGI:2677270Synonyms: A630041P07Rik, Pdzk8

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating aspartate transaminase level	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.02x10^-5
increased blood urea nitrogen level	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.32x10^-5
abnormal vibrissa morphology	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.59x10^-5
increased lean body mass	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.99x10^-5
increased large unstained cell number	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.74x10^-6
increased circulating amylase level	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.08x10^-6
hyperactivity	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.82x10^-6
increased mean platelet volume	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.55x10^-5
short tibia	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.34x10^-5
increased circulating triglyceride level	1 supporting dataset	Pdzd8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.83x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pdzd8.

Associated images

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Histopathology

There is no histopathology data found for Pdzd8.

IMPC related publications

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External links

No external links available for Pdzd8.

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*Pdzd8^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pdzd8^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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