Iqsec3 | IQ motif and Sec7 domain 3

GeneMGI:2677208Synonyms: synarfGEF, BRAG3

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Vision/eye Behavior/neurological Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased fasting circulating glucose level	1 supporting dataset	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	1.4x10^-5
decreased body length	1 supporting dataset	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	1.42x10^-7
decreased prepulse inhibition	5 supporting datasets	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	2.64x10^-38
decreased total retina thickness	1 supporting dataset	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	3.38x10^-7
decreased bone mineral density	1 supporting dataset	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	1.01x10^-8
decreased lean body mass	2 supporting datasets	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	6.44x10^-20
impaired glucose tolerance	1 supporting dataset	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	1.97x10^-6
increased total body fat amount	2 supporting datasets	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	1.85x10^-19
decreased thigmotaxis	1 supporting dataset	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	8.39x10^-5
decreased bone mineral content	2 supporting datasets	Iqsec3^{tm3b(KOMP)Wtsi}	homozygote	Early adult	7.21x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Iqsec3.

Associated images

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Histopathology

There is no histopathology data found for Iqsec3.

IMPC related publications

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External links

No external links available for Iqsec3.

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*Iqsec3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Iqsec3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Iqsec3^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Iqsec3^{tm3a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Iqsec3^{tm3b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Iqsec3^{tm3e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Iqsec3^{tm42046(L1L2_Pgk_PM)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Iqsec3^{tm42046(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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