Trpm6 | transient receptor potential cation channel, subfamily M, member 6

GeneMGI:2675603Synonyms: CHAK2

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating phosphate level1 supporting datasetTrpm6tm1b(KOMP)WtsiheterozygoteEarly adult4.71x10-5 
decreased mean corpuscular volume1 supporting datasetTrpm6tm1b(KOMP)WtsiheterozygoteEarly adult9.67x10-6 
increased grip strength2 supporting datasetsTrpm6tm1b(KOMP)WtsiheterozygoteEarly adult6.65x10-6 
abnormal eye anterior chamber depth1 supporting datasetTrpm6tm1b(KOMP)WtsiheterozygoteEarly adult2.89x10-5 
increased body length1 supporting datasetTrpm6tm1b(KOMP)WtsiheterozygoteEarly adult3.62x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Trpm6tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Trpm6tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Trpm6tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Trpm6tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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