Dsg1c | desmoglein 1 gamma

GeneMGI:2664358Synonyms: Dsg6

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:10Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased locomotor activity1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult3.95x10-45 
decreased anxiety-related response1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult2.67x10-6 
abnormal behavior1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult2.92x10-11 
increased circulating total protein level1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult2.52x10-6 
decreased thigmotaxis2 supporting datasetsDsg1cem1(IMPC)MbphomozygoteEarly adult2.69x10-11 
increased circulating calcium level1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult5.66x10-6 
increased circulating creatinine level1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult2.2x10-8 
increased circulating HDL cholesterol level1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult1.96x10-5 
increased circulating cholesterol level1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult2.21x10-7 
increased circulating serum albumin level1 supporting datasetDsg1cem1(IMPC)MbphomozygoteEarly adult1.8x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dsg1cem1(IMPC)MbpExon Deletionmouse

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