Dsg1b | desmoglein 1 beta

GeneMGI:2664357Synonyms: Dsg5

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Integument Vision/eye Hematopoietic system Skeleton

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal eyelid morphology	1 supporting dataset	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.97x10^-13
thrombocytopenia	1 supporting dataset	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.29x10^-5
abnormal coat appearance	2 supporting datasets	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.06x10^-6
abnormal iris morphology	1 supporting dataset	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.78x10^-5
abnormal lens morphology	1 supporting dataset	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.38x10^-5
increased bone mineral content	1 supporting dataset	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.68x10^-5
abnormal cornea morphology	1 supporting dataset	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.22x10^-8
cataract	1 supporting dataset	Dsg1b^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.38x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dsg1b.

Associated images

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Histopathology

There is no histopathology data found for Dsg1b.

IMPC related publications

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External links

No external links available for Dsg1b.

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*Dsg1b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dsg1b^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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