Rapgef2 | Rap guanine nucleotide exchange factor (GEF) 2

GeneMGI:2659071Synonyms: Pdzgef1, nRapGEP, +3 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal retina morphology	1 supporting dataset	Rapgef2^em1(IMPC)H	heterozygote	Early adult	1.15x10^-16
preweaning lethality, complete penetrance	1 supporting dataset	Rapgef2^em1(IMPC)H	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Rapgef2^em1(IMPC)H	heterozygote	Early adult	6.87x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Rapgef2^em1(IMPC)H	homozygote	E12.5	N/A ^*
increased circulating bilirubin level	1 supporting dataset	Rapgef2^em1(IMPC)H	heterozygote	Early adult	7.76x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rapgef2.

Associated images

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Histopathology

There is no histopathology data found for Rapgef2.

IMPC related publications

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External links

No external links available for Rapgef2.

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*Rapgef2^em1(IMPC)H*	Exon Deletion	‌	mouse
*Rapgef2^em2(IMPC)H*	Exon Deletion	‌	mouse
*Rapgef2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rapgef2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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