Phactr1 | phosphatase and actin regulator 1

GeneMGI:2659021Synonyms: 9630030F18Rik, Rpel1

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Vision/eye Hematopoietic system Skeleton Renal/urinary system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal eye morphology	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased leukocyte cell number	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	3.89x10^-6
increased bone mineral content	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Early adult	3.3x10^-8
enlarged lymph nodes	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal coat/ hair morphology	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Middle aged adult	2.95x10^-7
decreased circulating aspartate transaminase level	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	1.07x10^-24
enlarged spleen	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased circulating alanine transaminase level	1 supporting dataset	Phactr1^em1(IMPC)Mbp	homozygote	Late adult	2.77x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Phactr1.

Associated images

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Histopathology

There is no histopathology data found for Phactr1.

IMPC related publications

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External links

No external links available for Phactr1.

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*Phactr1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Phactr1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Phactr1^{tm44835(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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