Sox21 | SRY (sex determining region Y)-box 21

GeneMGI:2654070Synonyms: Sox25

Physiological systems

19 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

8 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:28Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal coat/ hair morphology	3 supporting datasets	Sox21^em1(IMPC)Mbp	homozygote	Early adult	3.97x10^-16
abnormal skin morphology	2 supporting datasets	Sox21^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased grip strength	2 supporting datasets	Sox21^em1(IMPC)Mbp	homozygote	Early adult	3.63x10^-7
abnormal lymph node morphology	2 supporting datasets	Sox21^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased circulating cholesterol level	1 supporting dataset	Sox21^em1(IMPC)Mbp	homozygote	Early adult	7.88x10^-9
increased neutrophil cell number	1 supporting dataset	Sox21^em1(IMPC)Mbp	homozygote	Early adult	4.37x10^-6
enlarged lymph nodes	2 supporting datasets	Sox21^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased monocyte cell number	2 supporting datasets	Sox21^em1(IMPC)Mbp	homozygote	Early adult	4.17x10^-8
decreased locomotor activity	2 supporting datasets	Sox21^em1(IMPC)Mbp	homozygote	Early adult	1.33x10^-12
increased mean corpuscular volume	1 supporting dataset	Sox21^em1(IMPC)Mbp	homozygote	Early adult	1.47x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sox21.

Associated images

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Histopathology

There is no histopathology data found for Sox21.

IMPC related publications

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External links

No external links available for Sox21.

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*Sox21^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Sox21^{tm464323(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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