Agap1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

GeneMGI:2653690Synonyms: Centg2, Ggap1

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Growth/size/body region Hearing/vestibular/ear Vision/eye Behavior/neurological Skeleton Craniofacial Mortality/aging

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



persistence of hyaloid vascular system	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.87x10^-15
abnormal skin coloration	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.23x10^-5
abnormal auditory brainstem response	5 supporting datasets	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.69x10^-10
abnormal tooth morphology	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.12x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.41x10^-7
abnormal iris morphology	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.47x10^-6
abnormal snout morphology	2 supporting datasets	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.54x10^-6
abnormal cranium morphology	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.41x10^-5
increased circulating potassium level	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.1x10^-5
abnormal lens morphology	1 supporting dataset	Agap1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.26x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Agap1.

Associated images

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Histopathology

There is no histopathology data found for Agap1.

IMPC related publications

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External links

No external links available for Agap1.

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*Agap1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Agap1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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