Prss53 | serine protease 53

GeneMGI:2652890Synonyms: BC039632

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased circulating total protein level	1 supporting dataset	Prss53^{em3(IMPC)Wtsi}	homozygote	Early adult	9.45x10^-6
increased circulating creatinine level	1 supporting dataset	Prss53^{em3(IMPC)Wtsi}	homozygote	Early adult	4.1x10^-5
abnormal hair growth	2 supporting datasets	Prss53^{em2(IMPC)Wtsi}	homozygote	Early adult	1.8x10^-6
absent pinna reflex	1 supporting dataset	Prss53^{em2(IMPC)Wtsi}	homozygote	Early adult	7.78x10^-7
decreased leukocyte cell number	1 supporting dataset	Prss53^{em3(IMPC)Wtsi}	homozygote	Early adult	3.82x10^-5
increased body length	1 supporting dataset	Prss53^{em3(IMPC)Wtsi}	homozygote	Early adult	1.75x10^-5
decreased circulating serum albumin level	1 supporting dataset	Prss53^{em3(IMPC)Wtsi}	homozygote	Early adult	3.74x10^-5
abnormal vibrissa morphology	1 supporting dataset	Prss53^{em1(IMPC)Wtsi}	homozygote	Early adult	8.65x10^-17

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prss53.

Associated images

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Histopathology

There is no histopathology data found for Prss53.

IMPC related publications

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External links

No external links available for Prss53.

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*Prss53^{em1(IMPC)Wtsi}*	Exon Deletion	‌	mouse
*Prss53^{em2(IMPC)Wtsi}*	Point Mutation	‌	mouse
*Prss53^{em3(IMPC)Wtsi}*	Point Mutation	‌	mouse
*Prss53^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Prss53^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Prss53^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Prss53^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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