Unc80 | unc-80, NALCN activator

GeneMGI:2652882Synonyms: C030018G13Rik, C230061B10Rik

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased body length	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	2.94x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Unc80^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	1.77x10^-13
abnormal retina morphology	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	1.44x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	1.93x10^-5
decreased circulating sodium level	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	6.03x10^-8
enlarged lymph nodes	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
abnormal retina blood vessel morphology	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	1.68x10^-5
decreased circulating chloride level	1 supporting dataset	Unc80^em1(IMPC)Tcp	heterozygote	Early adult	1.09x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Unc80.

Associated images

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Histopathology

There is no histopathology data found for Unc80.

IMPC related publications

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External links

No external links available for Unc80.

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*Unc80^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Unc80^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Unc80^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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