Tbc1d16 | TBC1 domain family, member 16

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Skeleton

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased bone mineral content1 supporting datasetTbc1d16em1(IMPC)JhomozygoteEarly adult7.85x10-5 
decreased bone mineral density1 supporting datasetTbc1d16em1(IMPC)JhomozygoteEarly adult1.13x10-5 
increased circulating alkaline phosphatase level1 supporting datasetTbc1d16em1(IMPC)JhomozygoteEarly adult7.27x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Order Mouse and ES Cells

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Tbc1d16em1(IMPC)JExon Deletionmouse
Tbc1d16tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Tbc1d16tm159(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Tbc1d16tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Tbc1d16tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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