Tph2 | tryptophan hydroxylase 2

Physiological systems

22 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Cardiovascular system Renal/urinary system Embryo Nervous system Vision/eye Liver/biliary system Behavior/neurological Mortality/aging

8 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:23Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased brain size	1 supporting dataset	Tph2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Tph2^em1(IMPC)Mbp	homozygote	Early adult	2.92x10^-6
small liver	1 supporting dataset	Tph2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Tph2^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
abnormal brain morphology	1 supporting dataset	Tph2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
increased eosinophil cell number	1 supporting dataset	Tph2^em1(IMPC)Mbp	homozygote	Early adult	4.75x10^-5
decreased locomotor activity	1 supporting dataset	Tph2^em1(IMPC)Mbp	homozygote	Early adult	5.66x10^-30
no spontaneous movement	1 supporting dataset	Tph2^em1(IMPC)Mbp	homozygote	E18.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Tph2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged ovary	1 supporting dataset	Tph2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tph2.

Associated images

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Histopathology

There is no histopathology data found for Tph2.

IMPC related publications

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External links

No external links available for Tph2.

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*Tph2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Tph2^{tm40059(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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