Cog3 | component of oligomeric golgi complex 3

GeneMGI:2450151

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

1Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Cog3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal lens morphology	3 supporting datasets	Cog3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.11x10^-5
increased circulating insulin level	1 supporting dataset	Cog3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.05x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cog3.

Associated images

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Histopathology

There is no histopathology data found for Cog3.

IMPC related publications

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External links

No external links available for Cog3.

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*Cog3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cog3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cog3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes