Adnp2 | ADNP homeobox 2

GeneMGI:2448562Synonyms: 8430420L05Rik, Zfp508

Physiological systems

21 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Nervous system Respiratory system Liver/biliary system Behavior/neurological Skeleton Mortality/aging

7 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:26Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased prepulse inhibition	2 supporting datasets	Adnp2^em3(IMPC)Tcp	homozygote	Early adult	1.16x10^-10
absent adrenal gland	1 supporting dataset	Adnp2^em3(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal bone structure	1 supporting dataset	Adnp2^em3(IMPC)Tcp	homozygote	Early adult	7.44x10^-5
short tibia	1 supporting dataset	Adnp2^em3(IMPC)Tcp	homozygote	Early adult	2.67x10^-11
decreased circulating serum albumin level	1 supporting dataset	Adnp2^em3(IMPC)Tcp	homozygote	Early adult	9.23x10^-5
small adrenal glands	1 supporting dataset	Adnp2^em3(IMPC)Tcp	heterozygote	Late adult	N/A ^*
small kidney	1 supporting dataset	Adnp2^em3(IMPC)Tcp	heterozygote	Late adult	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Adnp2^em3(IMPC)Tcp	homozygote	Early adult	N/A ^*
small uterus	1 supporting dataset	Adnp2^em3(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Adnp2^em3(IMPC)Tcp	heterozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Adnp2.

Associated images

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Histopathology

There is no histopathology data found for Adnp2.

IMPC related publications

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External links

No external links available for Adnp2.

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*Adnp2^em3(IMPC)Tcp*	Indel	‌	mouse
*Adnp2^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Adnp2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Adnp2^{tm445498(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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