Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
prenatal lethality | Cox18em1(IMPC)J | HOM | E18.5 | 0.00 | ||
embryonic lethality prior to tooth bud stage | Cox18em1(IMPC)J | HOM | E12.5 | 0.00 | ||
preweaning lethality, complete penetrance | Cox18em1(IMPC)J | HOM | Early adult | 0.00 | ||
embryonic growth retardation | Cox18em1(IMPC)J | HOM | E9.5 | 0.00 | ||
decreased prepulse inhibition | Cox18em1(IMPC)J | HET | Early adult | 4.07×10-06 | ||
abnormal neural tube closure | Cox18em1(IMPC)J | HOM | E9.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cox18 by phenotypic similarity.
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MGI Allele | Allele Type | Produced |
---|---|---|
Cox18em1(IMPC)J | Exon Deletion | Mice |
Cox18tm45902(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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