H4c1 | H4 clustered histone 1
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Integument Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
14 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal eye morphology | 1 supporting dataset | H4c1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased freezing behavior | 1 supporting dataset | H4c1em1(IMPC)Ccpcz | homozygote | Early adult | 3.05x10-7 | ||
| abnormal freezing behavior | 1 supporting dataset | H4c1em1(IMPC)Ccpcz | homozygote | Early adult | 1.04x10-5 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | H4c1em1(IMPC)Ccpcz | homozygote | Early adult | 4.08x10-7 | ||
| abnormal skin morphology | 1 supporting dataset | H4c1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | H4c1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by H4c1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for H4c1.
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| H4c1em1(IMPC)Ccpcz | Whole-gene deletion | | mouse |