Mgrn1 | mahogunin, ring finger 1

GeneMGI:2447670Synonyms: nc, 2610042J20Rik

Physiological systems

21 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Hematopoietic system Craniofacial Cardiovascular system Renal/urinary system Homeostasis/metabolism Pigmentation Behavior/neurological Skeleton Mortality/aging

6 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:26Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	2 supporting datasets	Mgrn1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased neutrophil cell number	2 supporting datasets	Mgrn1^em1(IMPC)Tcp	heterozygote	Early adult	1.9x10^-9
abnormal auditory brainstem response	6 supporting datasets	Mgrn1^em1(IMPC)Tcp	homozygote	Early adult	1.23x10^-10
decreased lymphocyte cell number	1 supporting dataset	Mgrn1^em1(IMPC)Tcp	heterozygote	Early adult	3.17x10^-8
increased heart weight	1 supporting dataset	Mgrn1^em1(IMPC)Tcp	heterozygote	Early adult	2.46x10^-5
enlarged urinary bladder	1 supporting dataset	Mgrn1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Mgrn1^em1(IMPC)Tcp	homozygote	Early adult	1.64x10^-7
shortened QRS complex duration	1 supporting dataset	Mgrn1^em1(IMPC)Tcp	heterozygote	Early adult	1.06x10^-6
enlarged lymph nodes	1 supporting dataset	Mgrn1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Mgrn1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mgrn1.

Associated images

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Histopathology

There is no histopathology data found for Mgrn1.

IMPC related publications

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External links

No external links available for Mgrn1.

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*Mgrn1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Mgrn1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Mgrn1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mgrn1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mgrn1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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