Ago1 | argonaute RISC catalytic subunit 1

GeneMGI:2446630Synonyms: Eif2c1, argonaute 1

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased body weight	4 supporting datasets	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.58x10^-10
preweaning lethality, incomplete penetrance	1 supporting dataset	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased lactate dehydrogenase level	1 supporting dataset	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.07x10^-7
increased circulating LDL cholesterol level	1 supporting dataset	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.14x10^-7
abnormal behavior	1 supporting dataset	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.22x10^-5
increased circulating cholesterol level	1 supporting dataset	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.56x10^-5
increased hematocrit	1 supporting dataset	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.9x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Ago1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.87x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ago1.

Associated images

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Histopathology

There is no histopathology data found for Ago1.

IMPC related publications

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External links

No external links available for Ago1.

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*Ago1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ago1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Ago1^{tm36769(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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