Sik3 | SIK family kinase 3

GeneMGI:2446296Synonyms: 9030204A07Rik, 5730525O22Rik

Physiological systems

19 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Pigmentation Integument Adipose tissue Obsolete decreased cd4-positive, alpha beta t cell number Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Craniofacial

6 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:77Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



kyphosis	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.71x10^-10
abnormal humerus morphology	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.51x10^-18
increased eosinophil cell number	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased CD5-positive gamma-delta T cell number	2 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased effector memory T-helper cell number	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased KLRG1-positive NK cell number	7 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal pelvic girdle bone morphology	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.51x10^-13
decreased alpha-beta T cell number	2 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal ulna morphology	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	3.82x10^-17
decreased Ly6C-positive mature NK cell number	2 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sik3.

Associated images

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Histopathology

There is no histopathology data found for Sik3.

IMPC related publications

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External links

No external links available for Sik3.

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*Sik3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sik3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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