Sik3 | SIK family kinase 3

GeneMGI:2446296Synonyms: 9030204A07Rik, 5730525O22Rik

Physiological systems

19 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Pigmentation Integument Adipose tissue Obsolete decreased cd4-positive, alpha beta t cell number Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Craniofacial

6 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:77Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



kyphosis	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.71x10^-10
abnormal humerus morphology	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.51x10^-18
increased eosinophil cell number	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased CD5-positive gamma-delta T cell number	2 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased effector memory T-helper cell number	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased KLRG1-positive NK cell number	7 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal pelvic girdle bone morphology	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.51x10^-13
decreased alpha-beta T cell number	2 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal ulna morphology	1 supporting dataset	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	3.82x10^-17
decreased Ly6C-positive mature NK cell number	2 supporting datasets	Sik3^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Sik3.

Associated images

Loading...

Histopathology

There is no histopathology data found for Sik3.

IMPC related publications

Loading...

External links

No external links available for Sik3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Sik3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sik3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes