Setd1a | SET domain containing 1A

GeneMGI:2446244Synonyms: KMT2F

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Skeleton

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lean body mass	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.39x10^-14
increased blood urea nitrogen level	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.08x10^-17
decreased leukocyte cell number	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.97x10^-13
decreased circulating LDL cholesterol level	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.49x10^-7
increased bone mineral density	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.42x10^-12
increased bone mineral content	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.83x10^-8
increased circulating creatinine level	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.43x10^-33
decreased circulating HDL cholesterol level	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.22x10^-8
increased circulating fructosamine level	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.15x10^-5
decreased circulating cholesterol level	1 supporting dataset	Setd1a^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.39x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Setd1a.

Associated images

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Histopathology

There is no histopathology data found for Setd1a.

IMPC related publications

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External links

No external links available for Setd1a.

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*Setd1a^{tm1(IMPC)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Setd1a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Setd1a^{tm1.2(IMPC)Wtsi}*	Reporter-tagged deletion allele (post Flp, with no reporter and selection cassette)	‌	mouse
*Setd1a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Setd1a^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Setd1a^{tm39777(L1L2_gt0_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Setd1a^{tm39777(pL1L2_frt15_BetactinBSD_frt14_neo_Rox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes