Ccdc186 | coiled-coil domain containing 186

GeneMGI:2445022Synonyms: Otg1, A630007B06Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system Mortality/aging Craniofacial

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal placenta morphology	2 supporting datasets	Ccdc186^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Ccdc186^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
edema	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Ccdc186^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ccdc186.

Associated images

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Histopathology

There is no histopathology data found for Ccdc186.

IMPC related publications

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External links

No external links available for Ccdc186.

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*Ccdc186^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ccdc186^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ccdc186^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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