Chfr | checkpoint with forkhead and ring finger domains

GeneMGI:2444898Synonyms: RNF116, 5730484M20Rik

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Immune system Integument Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system Cardiovascular system Renal/urinary system

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

27Embryo tissues

Phenotypes

Phy. System:



increased circulating alanine transaminase level	1 supporting dataset	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.88x10^-7
abnormal testis morphology	1 supporting dataset	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal skin coloration	2 supporting datasets	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.6x10^-5
abnormal spleen morphology	1 supporting dataset	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased lung elastance	2 supporting datasets	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.61x10^-5
thin ventricular wall	1 supporting dataset	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.54x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.84x10^-8
abnormal coat/hair pigmentation	3 supporting datasets	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.6x10^-5
small testis	1 supporting dataset	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Chfr^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.83x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chfr.

Associated images

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Histopathology

There is no histopathology data found for Chfr.

IMPC related publications

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External links

No external links available for Chfr.

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*Chfr^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Chfr^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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