Hpdl | 4-hydroxyphenylpyruvate dioxygenase-like

GeneMGI:2444646Synonyms: A830048M07Rik, Gloxd1

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Integument Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Mortality/aging

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:16Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased body length1 supporting datasetHpdlem1(IMPC)MbpheterozygoteEarly adult5.6x10-5 
abnormal vitreous body morphology1 supporting datasetHpdlem1(IMPC)MbpheterozygoteEarly adult3.17x10-5 
decreased thigmotaxis2 supporting datasetsHpdlem1(IMPC)MbpheterozygoteEarly adult6.09x10-5 
decreased prepulse inhibition1 supporting datasetHpdlem1(IMPC)MbpheterozygoteEarly adult6.71x10-5 
no spontaneous movement1 supporting datasetHpdlem1(IMPC)MbpheterozygoteE18.5N/A * 
enlarged heart1 supporting datasetHpdlem1(IMPC)MbpheterozygoteEarly adultN/A * 
decreased anxiety-related response1 supporting datasetHpdlem1(IMPC)MbpheterozygoteEarly adult8.09x10-6 
preweaning lethality, incomplete penetrance3 supporting datasetsHpdlem1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal skin morphology1 supporting datasetHpdlem1(IMPC)MbpheterozygoteEarly adultN/A * 
abnormal retina morphology1 supporting datasetHpdlem1(IMPC)MbpheterozygoteEarly adult7.23x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hpdlem1(IMPC)MbpWhole-gene deletionmouse
Hpdltm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell

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