Nlgn3 | neuroligin 3

GeneMGI:2444609Synonyms: NL3, HNL3, +2 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Skeleton

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hyperactivity	9 supporting datasets	Nlgn3^{em1(IMPC)Rbrc}	homozygote	Early adult	4.6x10^-35
hyperactivity	7 supporting datasets	Nlgn3^{em1(IMPC)Rbrc}	hemizygote	Early adult	6.19x10^-10
decreased anxiety-related response	1 supporting dataset	Nlgn3^{em1(IMPC)Rbrc}	homozygote	Early adult	1.08x10^-5
increased eosinophil cell number	2 supporting datasets	Nlgn3^{em1(IMPC)Rbrc}	hemizygote	Late adult	1.63x10^-12
abnormal locomotor activation	1 supporting dataset	Nlgn3^{em1(IMPC)Rbrc}	hemizygote	Late adult	9.32x10^-12
increased bone mineral density	1 supporting dataset	Nlgn3^{em1(IMPC)Rbrc}	hemizygote	Early adult	3.56x10^-8
abnormal blood uric acid level	1 supporting dataset	Nlgn3^{em1(IMPC)Rbrc}	hemizygote	Late adult	1.61x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nlgn3.

Associated images

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Histopathology

There is no histopathology data found for Nlgn3.

IMPC related publications

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External links

No external links available for Nlgn3.

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*Nlgn3^{em1(IMPC)Rbrc}*	Intra-exon deletion	‌	mouse
*Nlgn3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Nlgn3^{tm241191(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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