Mysm1 | myb-like, SWIRM and MPN domains 1

GeneMGI:2444584Synonyms: C530050H10Rik, C130067A03Rik

Physiological systems

20 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Immune system Integument Adipose tissue Growth/size/body region Hematopoietic system Craniofacial Cardiovascular system Renal/urinary system Homeostasis/metabolism Pigmentation Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Mortality/aging

5 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:68Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal behavior	17 supporting datasets	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.13x10^-20
hyperactivity	1 supporting dataset	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.03x10^-6
decreased erythrocyte cell number	2 supporting datasets	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.84x10^-35
increased IgG3 level	1 supporting dataset	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.09x10^-5
abnormal gait	1 supporting dataset	Mysm1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.95x10^-5
decreased leukocyte cell number	2 supporting datasets	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.31x10^-18
abnormal hindlimb morphology	1 supporting dataset	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.48x10^-5
abnormal vertebrae morphology	2 supporting datasets	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.48x10^-17
abnormal coat/hair pigmentation	2 supporting datasets	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.46x10^-17
decreased circulating cholesterol level	2 supporting datasets	Mysm1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.1x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mysm1.

Associated images

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Histopathology

There is no histopathology data found for Mysm1.

IMPC related publications

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External links

No external links available for Mysm1.

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*Mysm1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Mysm1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Mysm1^{tm355089(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Mysm1^{tm36374(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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