Nalcn | sodium leak channel, non-selective

GeneMGI:2444306Synonyms: Vgcnl1, A530023G15Rik

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Embryo Growth/size/body region Nervous system Hematopoietic system Cardiovascular system Mortality/aging Renal/urinary system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Nalcn^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
hemorrhage	1 supporting dataset	Nalcn^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
decreased lymphocyte cell number	1 supporting dataset	Nalcn^em1(IMPC)Mbp	heterozygote	Early adult	6.4x10^-5
increased neutrophil cell number	2 supporting datasets	Nalcn^em1(IMPC)Mbp	heterozygote	Early adult	9.66x10^-9
spina bifida	1 supporting dataset	Nalcn^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Nalcn^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
spina bifida	1 supporting dataset	Nalcn^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal spleen morphology	1 supporting dataset	Nalcn^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Nalcn^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Nalcn^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nalcn.

Associated images

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Histopathology

There is no histopathology data found for Nalcn.

IMPC related publications

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External links

No external links available for Nalcn.

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*Nalcn^em1(IMPC)Mbp*	Indel	‌	mouse
*Nalcn^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Nalcn^{tm119088(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Nalcn^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Nalcn^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Nalcn^{tm2(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse

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