Zzef1 | zinc finger, ZZ-type with EF hand domain 1

GeneMGI:2444286Synonyms: C130099L13Rik, 8430405D05Rik

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:74Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



increased coping response	1 supporting dataset	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	1.99x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	5.8x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	3.08x10^-5
increased mean corpuscular hemoglobin	2 supporting datasets	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	6.29x10^-7
abnormal sleep behavior	3 supporting datasets	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	4.9x10^-6
increased circulating potassium level	1 supporting dataset	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	1.77x10^-6
hyperactivity	1 supporting dataset	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	8.91x10^-5
abnormal coat/hair pigmentation	2 supporting datasets	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	1.76x10^-6
increased circulating alkaline phosphatase level	2 supporting datasets	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	1.88x10^-8
abnormal kidney morphology	1 supporting dataset	Zzef1^{tm2.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Zzef1.

Associated images

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Histopathology

There is no histopathology data found for Zzef1.

IMPC related publications

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External links

No external links available for Zzef1.

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*Zzef1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Zzef1^{tm2(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Zzef1^{tm2.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Zzef1^{tm251649(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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