Dennd5b | DENN domain containing 5B

GeneMGI:2444273Synonyms: 9330160C06Rik, D030011O10Rik

Physiological systems

18 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

8 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



prolonged PR interval	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	5.5x10^-5
increased lymphocyte cell number	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	5.03x10^-8
abnormal sternum morphology	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	4.65x10^-7
decreased total body fat amount	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	3.53x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	3.96x10^-23
improved glucose tolerance	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	1.25x10^-6
decreased circulating cholesterol level	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	1.35x10^-16
abnormal spleen morphology	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Dennd5b^em1(IMPC)Tcp	homozygote	Early adult	5.2x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dennd5b.

Associated images

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Histopathology

There is no histopathology data found for Dennd5b.

IMPC related publications

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External links

No external links available for Dennd5b.

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*Dennd5b^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Dennd5b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dennd5b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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