Lrig3 | leucine-rich repeats and immunoglobulin-like domains 3

GeneMGI:2443955Synonyms: 9030421L11Rik, 9430095K15Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Muscle Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating lactate dehydrogenase level	1 supporting dataset	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.47x10^-7
abnormal vertebral arch morphology	3 supporting datasets	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.63x10^-11
increased circulating aspartate transaminase level	1 supporting dataset	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.55x10^-5
abnormal skin morphology	2 supporting datasets	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skeletal muscle morphology	2 supporting datasets	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal digit morphology	1 supporting dataset	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.55x10^-7
enlarged heart	1 supporting dataset	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal vertebrae morphology	1 supporting dataset	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.03x10^-13
abnormal gait	1 supporting dataset	Lrig3^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.8x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lrig3.

Associated images

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Histopathology

There is no histopathology data found for Lrig3.

IMPC related publications

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External links

No external links available for Lrig3.

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*Lrig3^{em1(IMPC)Ccpcz}*	Inter-exon deletion	‌	mouse
*Lrig3^{tm208514(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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