Osbpl8 | oxysterol binding protein-like 8

GeneMGI:2443807Synonyms: ORP-8, D330025H14Rik

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Hearing/vestibular/ear Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased thigmotaxis	2 supporting datasets	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	5.04x10^-5
decreased prepulse inhibition	5 supporting datasets	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	4.64x10^-17
abnormal sternum morphology	1 supporting dataset	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	6 supporting datasets	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	5.71x10^-12
abnormal lens morphology	1 supporting dataset	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	1.5x10^-6
increased red blood cell distribution width	1 supporting dataset	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	1.47x10^-5
cataract	1 supporting dataset	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	1.89x10^-6
abnormal eye morphology	1 supporting dataset	Osbpl8^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Osbpl8.

Associated images

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Histopathology

There is no histopathology data found for Osbpl8.

IMPC related publications

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External links

No external links available for Osbpl8.

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*Osbpl8^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Osbpl8^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Osbpl8^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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