Ambra1 | autophagy/beclin 1 regulator 1

GeneMGI:2443564Synonyms: 2310079H06Rik, D030051N19Rik

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Skeleton Mortality/aging Craniofacial

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased prepulse inhibition	2 supporting datasets	Ambra1^em1(IMPC)Bay	heterozygote	Early adult	1.09x10^-5
spina bifida	1 supporting dataset	Ambra1^em1(IMPC)Bay	homozygote	E15.5	N/A ^*
increased total retina thickness	1 supporting dataset	Ambra1^em1(IMPC)Bay	heterozygote	Early adult	5.98x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Ambra1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
abnormal neural tube closure	1 supporting dataset	Ambra1^em1(IMPC)Bay	homozygote	E12.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Ambra1^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
abnormal cranium morphology	1 supporting dataset	Ambra1^em1(IMPC)Bay	homozygote	E12.5	N/A ^*
abnormal retina morphology	1 supporting dataset	Ambra1^em1(IMPC)Bay	heterozygote	Early adult	4.34x10^-5
prenatal lethality	1 supporting dataset	Ambra1^em1(IMPC)Bay	homozygote	E18.5	N/A ^*
abnormal tail morphology	1 supporting dataset	Ambra1^em1(IMPC)Bay	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ambra1.

Associated images

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Histopathology

There is no histopathology data found for Ambra1.

IMPC related publications

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External links

No external links available for Ambra1.

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*Ambra1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Ambra1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ambra1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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