Hook3 | hook microtubule tethering protein 3

GeneMGI:2443554Synonyms: E330005F07Rik, 5830454D03Rik

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Nervous system Respiratory system Hematopoietic system Behavior/neurological Skeleton

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.53x10^-6
increased basophil cell number	1 supporting dataset	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	2.14x10^-5
hyperactivity	2 supporting datasets	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	3.12x10^-5
abnormal lung morphology	1 supporting dataset	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	8.21x10^-5
decreased total body fat amount	1 supporting dataset	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	2.07x10^-8
increased grip strength	2 supporting datasets	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	5.42x10^-6
decreased prepulse inhibition	4 supporting datasets	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.39x10^-7
decreased bone mineral density	1 supporting dataset	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	4.49x10^-8
decreased body length	1 supporting dataset	Hook3^{tm1b(NCOM)Mfgc}	homozygote	Early adult	1.37x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Hook3.

Associated images

Loading...

Histopathology

There is no histopathology data found for Hook3.

IMPC related publications

Loading...

External links

No external links available for Hook3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Hook3^{tm1a(NCOM)Mfgc}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hook3^{tm1b(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

My Genes