Wdhd1 | WD repeat and HMG-box DNA binding protein 1

GeneMGI:2443514Synonyms: AND-1, D630024B06Rik

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Endocrine/exocrine gland Growth/size/body region Liver/biliary system Cardiovascular system Mortality/aging Renal/urinary system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



enlarged thyroid gland	1 supporting dataset	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
enlarged kidney	2 supporting datasets	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
enlarged heart	1 supporting dataset	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Wdhd1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
abnormal liver morphology	2 supporting datasets	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Wdhd1^{em1(IMPC)Rbrc}	homozygote	Early adult	N/A ^*
increased kidney weight	2 supporting datasets	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Late adult	1.6x10^-8
increased circulating bilirubin level	1 supporting dataset	Wdhd1^{em1(IMPC)Rbrc}	heterozygote	Early adult	4.5x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wdhd1.

Associated images

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Histopathology

There is no histopathology data found for Wdhd1.

IMPC related publications

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External links

No external links available for Wdhd1.

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*Wdhd1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Wdhd1^{em1(IMPC)Rbrc}*	Exon Deletion	‌	mouse
*Wdhd1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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