Tmc7 | transmembrane channel-like gene family 7

GeneMGI:2443317Synonyms: C630024K23Rik, 1700030H01Rik

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal eye morphology	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	1.15x10^-5
abnormal skin morphology	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
female infertility	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged spleen	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
microphthalmia	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Tmc7^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmc7.

Associated images

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Histopathology

There is no histopathology data found for Tmc7.

IMPC related publications

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External links

No external links available for Tmc7.

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*Tmc7^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Tmc7^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Tmc7^{tm380245(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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