Ttll1 | tubulin tyrosine ligase-like 1

GeneMGI:2443047Synonyms: 6330444E16Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased mean corpuscular hemoglobin concentration	1 supporting dataset	Ttll1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.72x10^-5
decreased hemoglobin content	1 supporting dataset	Ttll1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.7x10^-5
increased lean body mass	2 supporting datasets	Ttll1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.76x10^-6
abnormal tail movements	1 supporting dataset	Ttll1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.57x10^-5
increased IgE level	1 supporting dataset	Ttll1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.14x10^-5
increased total body fat amount	1 supporting dataset	Ttll1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.37x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Ttll1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased startle reflex	1 supporting dataset	Ttll1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.53x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ttll1.

Associated images

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Histopathology

There is no histopathology data found for Ttll1.

IMPC related publications

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External links

No external links available for Ttll1.

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*Ttll1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ttll1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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