Taf2 | TATA-box binding protein associated factor 2

GeneMGI:2443028Synonyms: TAFII150, 4732460C16Rik, +3 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Behavior/neurological Skeleton Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



hyperactivity	1 supporting dataset	Taf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.1x10^-7
increased circulating cholesterol level	1 supporting dataset	Taf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.32x10^-5
decreased grip strength	1 supporting dataset	Taf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.81x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Taf2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal cholesterol homeostasis	1 supporting dataset	Taf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.5x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Taf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.49x10^-6
long tibia	1 supporting dataset	Taf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.47x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Taf2.

Associated images

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Histopathology

There is no histopathology data found for Taf2.

IMPC related publications

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External links

No external links available for Taf2.

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*Taf2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Taf2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Taf2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Taf2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Taf2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Taf2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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