Arfgef1 | ADP ribosylation factor guanine nucleotide exchange factor 1

GeneMGI:2442988Synonyms: D130059B05Rik, BIG1, +3 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Hematopoietic system Behavior/neurological Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased locomotor activity	1 supporting dataset	Arfgef1^{em1(IMPC)Hmgu}	heterozygote	Early adult	1.52x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Arfgef1^{em1(IMPC)Hmgu}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Arfgef1^{em1(IMPC)Hmgu}	heterozygote	Early adult	7.94x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arfgef1.

Associated images

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Histopathology

There is no histopathology data found for Arfgef1.

IMPC related publications

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External links

No external links available for Arfgef1.

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*Arfgef1^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Arfgef1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Arfgef1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes