Ism1 | isthmin 1, angiogenesis inhibitor

GeneMGI:2442963Synonyms: 5430433G21Rik

Physiological systems

22 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Respiratory system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial Renal/urinary system

9 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



single kidney	2 supporting datasets	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal maxilla morphology	1 supporting dataset	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.27x10^-6
increased airway resistance	5 supporting datasets	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.72x10^-14
abnormal kidney morphology	2 supporting datasets	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged lymph nodes	2 supporting datasets	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.94x10^-5
abnormal lymph node morphology	2 supporting datasets	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.73x10^-5
abnormal thymus morphology	1 supporting dataset	Ism1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ism1.

Associated images

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Histopathology

There is no histopathology data found for Ism1.

IMPC related publications

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External links

No external links available for Ism1.

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*Ism1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Ism1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ism1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Ism1^{tm39456(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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