Mettl14 | methyltransferase 14, N6-adenosine-methyltransferase subunit

GeneMGI:2442926Synonyms: G430022H21Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Reproductive system Immune system Integument Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	2 supporting datasets	Mettl14^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Mettl14^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Mettl14^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Mettl14^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
abnormal uterus morphology	1 supporting dataset	Mettl14^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Mettl14^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Mettl14^em1(IMPC)Tcp	homozygote	E15.5	N/A ^*
decreased exploration in new environment	1 supporting dataset	Mettl14^em1(IMPC)Tcp	heterozygote	Early adult	4.44x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mettl14.

Associated images

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Histopathology

There is no histopathology data found for Mettl14.

IMPC related publications

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External links

No external links available for Mettl14.

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*Mettl14^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Mettl14^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mettl14^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mettl14^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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